OBJECTIVE： To provide scientific reference for rational， effective and economical drug use in pediatric department. METHODS： A total of 9 771 prescriptions were randomly selected from children’s branch of our hospital during May 2012-Apr. 2016. Those prescriptions were analyzed statistically in respects of drug type， prescription cost， utilization rate of injection， utilization rate of essential medicine， clinical diagnosis， irrational drug use， use of antibiotics， etc. RESULTS： Among 9 771 prescriptions， 2.91 types of drugs were used in each prescription， and each prescription expended 77.10 yuan； utilization rate of injection was 57.11％， and that of national essential medicine was 67.80％. Respiratory tract disease was main disease （84.17％）. There were 284 irrational prescriptions （2.91％）， including 156 non-standard prescriptions， 165 unsuitable prescriptions and 65 extraordinary prescriptions. Utilization rate of antibiotics was 18.25％， among which that of Cefoxitin sodium injection was the highest （15.48％）， but its utilization index was the lowest （0.58）. The detection rate of microorganism isolated from bronchitis patients was in low level （45.10％）. CONCLUSIONS： The rate of qualified prescription in the children’s branch of our Hospital is higher than the requirement of the former Ministry of Public Health concerning the rate of qualified prescription ＞95％； utilization rate of antibiotics and injection are both in high level. In the future， it is necessary to strengthen prescription evaluation and promote standard and rational use of drugs so as to guarantee safe， effective and economical use of drugs in clinic.