OBJECTIVE： To investigate the effects of methimazole combined with acupoint application on hormone levels and bone metabolism indexes of patients with hyperthyroidism. METHODS： 150 hyperthyroidism patients were randomly divided into group A （50 cases）， group B （50 cases） and group C （50 cases）. Based on routine treatment， group A was given Methimazole tablets orally， with initial dose of 20-40 mg， 1-2 times a day； 2-6 weeks later， reducing and maintaining at 2.5-10 mg if the disease condition was improved； maintaining 20-40 mg if no improvement. Group B was acupoint application， one piece， pasting on Zusanli， Sanyinjiao， Shenmen， Taichong， Neiguan points 1 h after breakfast. Group C received Methimazole tablets （same usage and dosage as group A）+acupoint application （same usage and dosage as group B）. Treatment courses of 3 groups lasted for 2 months. The levels of TSH， FT3， FT4， T3， T4， T， E2， LH， FSH， CT， BGP and PTH were observed in 3 groups before and after treatment， and the occurrence of ADR was also observed. RESULTS： Before treatment， there was no statistical significance in the levels of above indexes among 3 groups （P＞0.05）. After treatment， the levels of TSH and PTH in 3 groups were significantly higher than before， and the group C was significantly higher than the group A and B. The levels of FT3， FT4， T3， T4， T， E2， LH， FSH， CT and BGP in 2 groups were significantly lower than before， and the group C was significantly lower than the group A and B； there was statistical significance （P＜0.05）. There was no statistical significance in each index between group A and B （P＞0.05）. There was no statistical significance in the incidence of ADR among 3 groups （P＞0.05）. CONCLUSIONS： Based on routine treatment， methimazole combined with acupoint application can significantly improve the thyroid function， correct the disorder of sex hormones and abnormal bone metabolism in hyperthyroidism patient， without increasing the incidence of ADR.