OBJECTIVE: To establish the quality standard for Compound qima capsules. METHODS: TLC was used for the qualitative identification of Radix astragali, Gastrodia elata, Pummelo Peel and Ligusticum chuanxiong. HPLC method was adopted for the contents determination of gastrodin and gastrodigenin. The determination wasp performed on Waters XBridge C18 column with mobile phase consisted of acetonitrile-0.05% phosphoric acid (3 ∶ 97,V/V) at the flow rate of 1.0 mL/min. The detection wavelength was set at 220 nm, column temperature was 25 ℃ and sample size was 10 μL. RESULTS: The TLC spots of R. astragali, G. elata, Pummelo Peel and L. chuanxiong were clear and well separated without the interference of negative samples. The linear ranges of gastrodin and gastrodigenin were 7.97-59.76 μg/mL(r=0.999 5),4.27-32.04 μg/mL(r=0.999 9). RSDs of precision, stability and repeatability tests were all lower than 1.0%. Recoveries of them were 98.98%-100.11%(RSD=0.35%,n=9), 98.74%-100.23%(RSD=0.43%,n=9), respectively. CONCLUSIONS: Established method can be used for quality control of Compound qima capsules.