OBJECTIVE： To observe clinical efficacy and safety of Xuebijing injection combined with imipenem and cilastation in the treatment of severe abdominal infection， and its effects on plasma endotoxin and inflammatory factors. METHODS： During Apr. 2013-Apr. 2016， 100 patients with severe abdominal infection in our hospital were divided into observation group and control group according to random number table， with 50 cases in each group. Both groups were given Imipenem and cilastation sodium for injection 0.5 g added into 0.9％ Sodium chloride injection 500 mL， ivgtt （≥40 min）， q12 h.  Eight hours later， observation group was additionally given Xuebijing injection 100 mL added into 0.9％ Sodium chloride injection 500 mL， ivgtt， bid； Both groups were treated for 5-7 d. The levels of plasma endotoxin and inflammatory factors （TNF-α， IL-6， IL-6/IL-10） were compared in 2 groups before after treatment， and clinical efficacies and the occurrence of ADR was recorded. RESULTS： Before treatment， there was no statistical significance in plasma endotoxin or inflammatory factor levels between 2 groups （P＞0.05）. After treatment， plasma endotoxin and inflammatory factor levels of 2 groups were decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. The excellent and good rate of observation group was 98.00％， which was significantly higher than 78.00％， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Xuebijing injection combined with imipenem and cilastation show significant therapeutic efficacy for severe abdominal infection， can effectively control the release of endotoxin and inflammatory factors with good safety.