OBJECTIVE： To investigate the utilization of opioid analgesic drugs in a hospital， so as to provide reference for rational drug use in clinic. METHODS： The utilization of opioid analgesic drugs in the hospital during 2014-2016 was analyzed and compared retrospectively in terms of consumption sum， DDDs， DDC， B/A， etc. RESULTS： Annual consumption sum of opioid analgesic drugs in the hospital increased slightly in 2015， but decreased significantly in 2016. Fentany transdermal patches （8.4 mg）， Oxycodone and acetaminophen tablets and Remifentanil hydrochloride for injection always took up the first 3 places in the list of DDDs. DDDs of Fentanyl citrate injection（0.1 mg） and Morphine sulfate sustained-release tablets increased year by year； while DDDs of Fentany transdermal patches （4.2 mg） and Fentany transdermal patches （8.4 mg） decreased year by year. DDC of all opioid analgesic drugs decreased in 2016， with the cancel of drug price addition at the end of 2016. B/A values of most drugs were close to 1.0； while B/A value of Oxycodone hydrochloride sustained-release tablets （40 mg） was much less than 1.0， and that of Fentany transdermal patches （8.4 mg） and Oxycodone and acetaminophen tablets were significantly more than 1.0 for consecutive 3 years. CONCLUSIONS： The variety and specifications of opioid analgesic drugs in the hospital is comprehensive during 2014-2016. The clinical utilization of opioid analgesic drugs is generally rational， but still needs to be supervised effectively and particularly， so as to improve standard use of opioid andalgesic drugs.