OBJECTIVE： To investigate the early changes of ECG， cTnⅠ， LDH， α-HBDH and CKMB in patients with anthracyclines chemotherapy-induced heart damage after breast cancer surgery， and to explore their significances in the diagnosis of early heart damage. METHODS： Medical information of 152 cases of anthracyclines chemotherapy after breast cancer surgery in our hospital during Jan. 2015-Jun. 2016 were analyzed retrospectively. According to diagnosis criteria of drug-induced cardiotoxicity， the occurrence of heart damage was evaluated during hospitalization and 1-year follow-up. According to evaluation results， those patients were divided into heart damage group（50 cases） and control group （102 cases）. The early changes of ECG， cTnⅠ， LDH， CKMB and α-HBDH were analyzed before chemotherapy （T0）， 24 h after first chemotherapy （T1）， 24 h after second chemotherapy （T2）， 24 h after forth chemotherapy. RESULTS： At T1，T2，T3， the proprotion of ECG abnormalities in heart damage group was significantly higher than control group； the serum levels of cTnⅠ， LDH， CKMB and α-HBDH in heart damage group were significantly higher than control group， with statistical significance （P＜0.01）. CONCLUSIONS： For anthracyclines chemotherapy drugs-induced heart damage after breast cancer surgery， early regular monitoring of ECG， cTnⅠ， LDH， CKMB and α-HBDH can improve the efficiency of early diagnosis of heart damage， and improve prognosis.