OBJECTIVE： To provide reference for the establishment of work mode of automatic dispensing system in large-scale integrated pharmacy. METHODS： Introducing the establishment and optimization situation of the automatic pharmacy dispensing system in the outpatient pharmacy of our hospital， changes of related deployment indexes before and after optimization were compared， and the main measures for improving the work efficiency of automatic dispensing system were explored. RESULTS： Based on setting and regularly adjusting stored drug varieties， numbers of occupied tracks and unbundled drug factors， designing deployment operation mode that the system automatically dispensing preparations to immediate-dispensing and pre-dispensing windows， establishing operational specifications and management refinement， the outpatient pharmacy had established automatic dispensing system with prescription deployment number more than 12 000 pieces/d and optimized work mode. Compared with before optimization， host， auxiliary and smart cabinet varieties were increased in the case of the same number of total staff， immediate-dispensing windows were increased and pre-dispensing windows were decreased. Proportion of full-automatically-dispensed prescriptions was increased （up from 41.18％ to 48.32％） in the case of total prescription increasing in peak hours， and numbers of hourly prescription deployment were increased in both immediate-dispensing and pre-dispensing windows. Average time to wait for medicine of patients was shortened （down from 5.63 min to 5.18 min）， supplemental medicine error and inner errors rate of deployment （down from 0.48％ to 0.44％） were decreased （P＜0.05）. CONCLUSIONS： The established automatic dispensing system mode can meet the needs of prescription deployment in large-scale integrated outpatient pharmacy， and improve the work efficiency by continually optimization.