OBJECTIVE： To establish a method for the content determination of cabozantinib in its raw material. METHODS： RP-HPLC method was adopted. The determination was performed on Inertsil ODS-SP C18 column with mobile phase consisted of acetonitrile-0.02 mol/L ammonium acetate buffer （pH 5.2，52 ∶ 48，V/V） at the flow rate of 1.0 mL/min. Detection wavelength was set at 241 nm， the column temperature was 38 ℃， and sample size was 20 μL. RESULTS： The linear range of cabozantinib were 9.88-49.40 μg/mL （r＝0.999 9）. The limit of quantitation was 11.46 ng， and the limit of detection was 3.36 ng. The RSDs of precision， stability， repeatability tests were all lower than 2.0％； recoveries were 98.5％-101.7％ （RSD＝1.2％，n＝9）. CONCLUSIONS： The method is simple， accurate and suitable for the content determination of cabozantinib in its raw material.