OBJECTIVE： To explore the role of clinical pharmacists in perioperative pharmaceutical care for patients with low rectal cancer （LRC）. METHODS： Clinical pharmacists participated in the perioperative drug therapy and pharmaceutical care for a LRC patient. They assisted physicians to develop pharmaceutical care from aspects of medication objective， individual medication， evaluation of medication rationality. RESULTS： Clinical pharmacists provided medication education for patients， bowel preparation and preanesthetic medication before surgery and offered drug therapy monitoring of fluid replacement， nutritional support， analgesia， expectorcont， hemostasis， anti-infective agents and antitumor agents. The patient was discharged successfully. CONCLUSIONS： Clinical pharmacists participate in perioperative pharmaceutical care and adjust medication timely according to disease condition to reduce postoperative complications and ADR， guarantee the safety of drug use and promote rational drug use during perioperative period.