OBJECTIVE： To provide reference for improving the quality of clinical pharmacy undergraduates in our university. METHODS： Considering about the practice problems of clinical pharmacy undergraduates in our university， pilot reform was conducted in the First Affiliated Hospital of our university in respects of teacher arrangement， department rotation assignment， assessment method. RESULTS： For new practice mode， in term of teacher arrangement， when the students were practicing in clinical pharmacy department， they were taught by clinical doctors and pharmacists； teacher training should be strengthened， and a variety of teaching methods was carried out. In term of department rotation assignment， to shorten the practice time of basic pharmacy department， and increase the clinical pharmacy practice department and practice time； to integrate the content of clinical medicine and clinical pharmacy practice， and select clinical medical departments equipped with clinical pharmacists to practice. In term of assessment method， there were 3 aspects including clinical pharmacy practice skills assessment， drug-related theory examination and basic situation assessment during internship. CONCLUSIONS： The new practice mode focuses on clinical pharmacy application skills training and students practical skills assessment， contributes to cultivate students’ thinking of rational drug use and improves clinical practice skill of students. It is suitable for clinical pharmacy undergraduate internship of our university.