OBJECTIVE： To investigate the compatible stability of cefpirome sulfate with ornidazole. METHODS： At room temperature [（20±1） ℃]， the appearances （color， clarity， sedimentation and gas） and pH changes of the mixtures by Cefpirome sulfate for injection with Ornidazole for injection in 0.9％ Sodium chloride injection and 5％ Glucose injection after 0， 1， 2， 4， 6 h were observed. RP-HPLC was adopted to determine its content changes. RESULTS： No significant change was noted for the mixture in appearance within 6 h， pH value ranged in 3.359-3.588； compared with the beginning （0 h）， the contents of cefpirome sulfate and ornidazole ranged in 100.2％-100.3％， 99.9％-100.4％ in 0.9％ Sodium chloride injection at each time point， as well as 99.7％-99.9％， 99.4％-99.6％ in 5％ Glucose injection. CONCLUSIONS： At room temperature， cefpirome sulfate mixed with ornidazole show stable appearance， pH value and content in 0.9％ Sodium chloride injection and 5％ Glucose injection within 6 h.