OBJECTIVE： To investigate the compatible stability of Levetiracetam （Lev） injection with 3 injections. METHODS： Each Lev injection 1 000 mg mixed with 0.9％ Sodium chloride injection 100 mL， 5％ Glucose injection 100 mL or Sodium lactate Ringer’s injection 100 mL respectively. Under the light condition， at 25 ℃， the color and clarification degree of mixtures were observed at different time points within 24 h after mixing； pH value and the number of insoluble particles were determined. The contents of related impurities （impurity A， B， C， D， 2-hydroxypyridine） and Lev in mixtures were determined by HPLC. RESULTS： Under above condition， all mixtures were colorless clear liquid within 24 h； pH value had no significant change （RSD＜1％，n＝7）； the number of insoluble particles was no more than the range stated in Chinese Pharmacopeia （2015 edition）. Impurity B and C were not detected； the contents of other impurities were in line with the requirements of foreign pharmacopeia. No marked change was noted for relative content of Lev （RSD＜1％，n＝7）. CONCLUSIONS： After mixing with 0.9％ Sodium chloride injection， 5％ Glucose injection or Sodium lactate Ringer’s injection， Lev injection keep stable at 25 ℃ within 24 h under the light condition.