OBJECTIVE： To systematically evaluate therapeutic efficacy of Yanhuning injection in the  treatment of epidemic mumps， explore valid way of evidence-based review， provide reference for the selection of new essential medicine list. METHODS： Retrieved from PubMed， CJFD，Wanfang database and VIP， randomized controlled trials （RCTs） about Yanhuning injection alone or combined with other positive drugs （trial group） vs. other positive drugs （control group） in the treatment of epidemic mumps. Meta-analysis was conducted by using Rev Man 5.3 statistical software after quality evaluation by modified Jadad scale. RESULTS： Totally 26 RCTs were included，involving 2 613 patients. Results of Meta-analysis showed， overall response rate [OR＝5.28，95％CI（3.92，7.11），P＜0.001] of trial group was significantly higher than that of control group； defervescence time [MD＝－1.97，95％CI（－2.83，－1.12），P＜0.001]， swelling disappearance time [MD＝－2.05，95％CI（－2.53，－1.58），P＜0.001] and pain disappearance time [MD＝－1.39，95％CI（－2.02，－0.75），P＜0.001] of trial group were significantly shorter than those of control group， there was statistical significance. CONCLUSIONS： Yanhuning injection has good curative effect for epidemic mumps， and can significantly shorten defervescence time， swelling disappearance time and pain disappearance time.