OBJECTIVE： To investigate the effects of Compound changpu yizhi decoction combined with nimodipine on clinical symptoms， cognitive function and cerebral blood flow velocity of patients with mild cognitive impairment （MCI） after stroke， and its medication safety. METHODS： 84 MCI patients after stroke in our hospital from Feb. 2012 to Oct. 2014 were selected as research objects and randomly divided into observation group and control group， 42 cases in each group. All patients received basic preventive treatment； control group was additionally given Nimodipine tablet 30 mg， tid， po； based on it， observation group was given Compound changpu yizhi decoction， one dose a day， taking with warm water every morning and evening. They were treated for 3 months. Clinical symptoms of patients were compared by vascular dementia TCM syndrome table before and after treatment， mini-mental state examination （MMSE） was used to compare the cognitive function of patients before and after treatment， cerebral blood flow velocity before and after treatment and incidence of adverse reactions in 2 groups were compared. RESULTS： Before treatment， there was no statistical significance in clinical symptom scores， cognitive function score and blood flow velocity of main artery between 2 groups （P＞0.05）. Clinical symptom scores of 2 groups were decreased significantly， while cognitive function and cerebral blood flow velocity were increased significantly； there was statistical significance， compared to before treatment （P＜0.05）. Memory scores， pain scores， complexion scores， tongue scores， pulse scores， additional scores and total scores in observation group were obviously lower than control group； orientation ability scores， recall ability scores， language skills scores and comprehensive cognitive function scores in observation group were obviously higher than control group； blood flow velocities of anterior cerebral artery， middle cerebral artery， posterior cerebral artery， vertebral artery and basilar artery in observation group were obviously faster than control group， with statistical significances （P＜0.05）. The incidence of ADR in observation group and contral group were 11.90％ and 9.52％， there was no statistical significance between 2 groups （P＞0.05）. CONCLUSIONS： Compound changpu yizhi decoction combined with nimodipine helps to relieve clinical symptoms of MCI patients after stroke， improve cerebral blood circulation and cognitive function， with good safety.