OBJECTIVE： To compare the effects of repeated subcutaneous insulin administration vs. insulin pump continuous subcutaneous administration on related indexes of advanced age patients with gestational diabetes mellitus （GDM）. METHODS： In retrospective study， 120 advanced age patients with GDM were randomly divided into group A （60 cases） and group B （60 cases）. Group A was given Insulin aspart injection with initial dose of 0.5 U/（kg·d） subcutaneously before meal， adjusted according to fasting blood glucose （FPG） and postprandial 2 h blood glucose （2 hPG）， and then given Isophane protamine biosynthetic human insulin injection with initial dose of 0.5 U/（kg·d） subcutaneously at bedtime， adjusted according to FPG and 2 hPG. Group B was given Insulin aspart injection with initial dose of 0.5 U/（kg·d） added into insulin pump using 40％ of total daily insulin as basic pump， increasing to 60％ of total daily insulin if blood glucose control was poor， adjusted according to FPG and 2 hPG. Treatment course of 2 groups lasted for 4 weeks. The time of blood glucose reaching target， the amount of insulin were observed in 2 groups， and the levels of FPG， 2 hPG， HbA1c， Hcy and Cys-C before and after treatment， the occurrence of patients and neonates complications. RESULTS： The time of blood glucose reaching standard in group B was significantly shorter than group A； the amount of insulin， the incidence of hypoglycemia， premature birth， excessive amniotic fluid and gestational hypertension in group B were significantly lower than group A， with statistical significance （P＜0.05）. The incidence of neonatal respiratory distress syndrome in group B was significantly lower than group A， with statistical significance （P＜0.05）；but there was no statistical significance in the incidence of giant baby and malformation between 2 groups （P＞0.05）. After treatment， the levels of FPG， 2 hPG， HbA1c， Hcy and Cys-C in 2 groups were significantly lower than before treatment， and the group B was significantly lower than the group A， with statistical significance（P＜0.05）. CONCLUSIONS： The insulin pump continuous subcutaneous administration is significantly better than repeated subcutaneous insulin administration in respects of controlling glucose level， reducing the amount of insulin， the levels of Cys-C and Hcy， maternal and neonatal complications.