OBJECTIVE： To study the protective effects of total flavone from Prunus cerasifera fruits （PCE） on alcoholic liver disease （ALD） in rats， and provide experimental basis for developing new medicines for anti-ALD. METHODS： 40 rats were randomly divided into normal group （distilled water）， model group （distilled water）， silibinin group [positive control， 30 mg/（kg·d）] and PCE high-dose， low-dose groups [80， 40 mg/（kg·d）]， 8 in each group. All rats were intragastrically administrated （10 mL/kg） every morning， once， for 6 weeks； meanwhile， except for normal group， rats in other groups received 50％ alcohol （10 mL/kg） once intragastrically every afternoon to induce ALD model. After administration， heart， liver， spleen and other organ indexes， subcutaneous fat， brown fat， abdominal fat indexes were determined， as well as serum biochemical indexes [glutamate transaminase （ALT）， aspartate aminotransferase （AST）， total bilirubin （TBIL）， direct bilirubin （DBIL）， indirect bilirubin （IBIL）， gamma-glutamyl transpeptidase （GGT）， and total cholesterol （TC）， triglyceride （TG）， high-density lipoprotein （HDL）， low-density lipoprotein （LDL）] level and liver biochemical indexes [superoxide dismutase （SOD）， malondialdehyde （MDA）， glutathione peroxidase （GSH-Px）， TC， TG] and TC， TG levels in feces； pathological changes of liver and kidney tissues were observed. RESULTS： Compared with normal group， heart， liver， spleen indexes， subcutaneous fat， abdominal fat indexes in model group were increased （P＜0.05 or P＜0.01）， brain index and brown fat index were decreased （P＜0.05）； HDL level and HDL/TC ratio in serum were decreased， other serum indexes were increased （P＜0.05 or P＜0.01）； SOD， GSH-Px levels in liver tissue were decreased， other above-mentioned liver biochemical indexes were increased （P＜0.01）； TC， TG levels in feces were increased （P＜0.01）； liver and kidney showed obvious lesions. Compared with model group， the above-mentioned indexes in silibinin group and PCE high-dose group were significantly improved （P＜0.05 or P＜0.01）； ALT， AST in serum and MDA level in liver tissue in PCE low-dose group were significantly decreased （P＜0.01）， and SOD， GSH-Px levels in liver tissue were significantly increased （P＜0.05）； lesion degree of liver and kidney and lipid accumulation in liver were reduced in administration groups. CONCLUSIONS： PCE may play a role in anti-ALD by anti-oxidation， promoting liver cell regeneration and regulating lipid metabolism.