OBJECTIVE： To screen the matrix formulation of Indomethacin hydrophilic gel patch. METHODS： Using appearance， adhesion， softness， moisture retention as indexes， mixed level of uniform design was used to screen matrix formulation of patch， verification test and in vitro transdermal test were used to evaluate the patch quality. RESULTS： Optimized matrix formulation was as follow as PVA of 7.686 g， PVP of 9.662 g， glyceryl of 19.992 g， gelatin of 9.999 g， CMC-Na of 13.997 g， carbomer of 3.000 g， HPMC of 1.500 g. The prepared patch had smooth surface， uniform matrix， good color， strong adhesion， good softness （water loss rate of 11.9％）. It can be slowly released for 48 h. The in vitro transdermal release fitted the Higuchi model （R2＝ 0.986 9）. CONCLUSIONS： Indomethacin hydrophilic gel patch is successfully prepared， which can slowly release drug with overall good quality.