OBJECTIVE： To study the effects of Ⅰ， Ⅱ crystal and amorphous forms of lercanidipine hydrochloride on the preparation， and provide theoretical basis for its development and consistency evaluation. METHODS： X-ray powder diffraction （XRD）， infrared spectrophotometry （IR） and differential scanning calorimetry （DSC） were adopted to identify the 3 crystal forms of lercanidipine hydrochloride. XRD was used to compare the effects of crushing， grinding， pressing technology， wetting granulation， adhesive solvents （water， ethanol） and drying temperature （50， 60， 70 ℃） on stability of 3 crystal forms of lercanidipine hydrochloride； the dissolution in vitro in water， hydrochloride， pH 4.5 acetate buffer， pH 6.8 phosphate buffer were compared among 3 crystal forms of Lercanidipine hydrochloride tablet. RESULTS： XRD showed both Ⅰ， Ⅱ crystal forms had characteristic diffraction peak with inconsistent 2 θ values， amorphous had no characteristic diffraction peak； IR showed 3 crystal forms had different absorption intensity and absorption peak number； DSC showed Ⅰ， Ⅱ crystal forms had obvious endothermic peak in 194.6 ℃， 207.3 ℃， respectively， amorphous had obvious endothermic peak in 86.1 ℃ and exothermic peak in 299.8 ℃. Crushing， grinding， pressing and drying temperature had no effects on the stability of 3 crystal forms； water had no effect on the stability of crystal in wetting granulation， ethanol may cause the change of Ⅰcrystal form. Except for the comparison between Ⅰ， Ⅱ crystal forms in hydrochloride （f2＝68）， the dissolution f2 of 3 crystal forms in 4 kinds of medium were lower than 50. CONCLUSIONS： XRD， IR， DSC methods can identify the 3 crystal forms of Lercanidipine hydrochloride tablet. When preparing lercanidipine hydrochloride by Ⅰcrystal form， wetting granulation should avoid using ethanol as a adhesive solvent， instead of water. Different crystal forms can affect the dissolution in vitro of prepared Lercanidipine hydrochloride tablet.