OBJECTIVE： To observe analgesic efficacy of oxycodone acetaminophen after posterior lumbar fusion， and to optimize spinal postoperative analgesia plan. METHODS： In retrospective study， 120 patients underwent posterior lumbar fusion were selected from the Affiliated People’s Hospital of Hubei Medical College during Jun. 2013-Jun. 2014， and then divided into observation group and control group according to therapy plan， with 60 cases in each group. Observation group was given oxycodone acetaminophen 330 mg orally 6 h after surgery， and then 330 mg orally on 1st， 2nd day after surgery， tid. Control group was given celecoxib 200 mg 6 h after surgery， and then 200 mg on 1st， 2nd day after surgery， bid. Postoperative analgesic efficacy （VAS score） at resting state and active state，postoperative gastrointestinal motility recovery （the time to flatus） and the occurrence of ADR were observed in 2 groups after surgery. RESULTS： Whether at the resting state or the active state 24， 48， 72， 120 h after surgery， VAS score of observation group was significantly lower than that of control group， with statistical significance （P＜0.05）. There was no statistical significance in the time to flatus and the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Oral administration of oxycodone acetaminophen possesses good effect to relieve spinal postoperative pain， showing fast and safe analgesic efficacy.