OBJECTIVE： To provide reference for improving the quality of talent training for medical direction of chain management major in higher vocational college. METHODS： The situation of pharmaceutical retail chain industry market was analyzed in China； the problems of talent training mode were summarized to put forward reform plan and measures according to disadvantages. RESULTS： Based on the market situation as continues expansion of pharmaceutical retail chain industry market scale， shortage of professional talent pool， the formulation of new retail mode in China， and training mode situation as not enough in-depth cooperation between college and enterprise， poor practicality and pertinence of course setting， irrational teachers’ structure， teaching reform could be conducted on the basis of modern apprenticeship system in following aspects， such as college and enterprise shared the responsibility of training and cultivating， student admission is recruitment； college and enterprise designed curriculum system and assessed students together； “double tutor” team of college teacher and enterprise teacher was constructed. CONCLUSIONS： The talent training mode based on modern apprenticeship system is the entry point for teaching reform of medical direction of chain management major in higher vocational college， which is conducive to cultivate high quality pharmaceutical management talents meeting industry needs and social development.