OBJECTIVE： To improve the quality standard for Guibi zhitong liquor. METHODS： TLC was used for the qualitative identification of Radix angelicae， Notopterygium incisum， Radix aucklandiae and Magnolia officinalis in the preparation； HPLC was used for the contents determination of imperatorin and cinnamaldehyde： the column was Waters Symmetry Shield RP-C18 with mobile phase of methanol-water for imperatorin （60 ∶ 40，V/V） and methanol-water for cinnamaldehyde （35 ∶ 65，V/V） at a flow rate of 1.0 mL/min， detection wavelength was 254 nm for imperatorin and 290 nm for cinnamaldehyde， column temperature was 25 ℃， and the injection volume was 20 μL. RESULTS： The TLC spots of R. angelicae， N. incisum， R. aucklandiae and M. officinalis were clear and well separated， negative control without interference. The linear range was 3.0-30.0 μg/mL for imperatorin （r＝0.999 8） and 3.978-39.78 μg/mL for cinnamaldehyde （r＝0.999 9）； RSDs of precision， stability and reproducibility tests were lower than 2.0％； recoveries were 96.94％-102.64％（RSD＝2.37％，n＝6） and 96.78％-99.53％ （RSD＝1.00％，n＝6）. CONCLUSIONS： The improved standard more effectively control the quality of the Guibi zhitong liquor.