OBJECTIVE： To investigate the effects of tramadol combined with midazolam on prognosis of  patients underwent tumor resection in gastrointestinal surgery department. METHODS： In retrospective study， 200 tumor patients of gastrointestinal surgery department were divided into observation group （100 cases） and control group （100 cases）. Observation group was given Tramadol hydrochloride tablet 100 mg， 3 times a day+Midazolam injection 30 mg， added into 0.9％ Sodium chloride injection 60 mL， via intravenous pump， 2.5 mL/h， for consecutive 24 h， for consecutive 3 d. Control group was given Tramadol hydrochloride injection 100 mg， intramuscular injection， 3 times a day， for 3 d. The hospitalization duration， postoperative ambulation time， sleep quality score， pain degree score， the occurrence of postoperative hypostatic pneumonia，and the incidence of adverse reactions in 2 groups were observed. RESULTS： The hospitalization duration and postoperative ambulation time of observation group were significantly shorter than those of control group； the sleep quality score of observation groups was significantly higher than that of control group； the severity of pain， the incidence of hypostatic pneumonia were significantly lower than control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Midazolam combined with tramadol can significantly reduce the postoperative pain of tumor patients in gastrointestinal tumor surgery department， shorten hospitalization time and postoperative ambulation time， improve the sleep quality of patients and reduce the incidence of hypostatic pneumonia with good safety.