OBJECTIVE： To optimize the extraction technology of asiaticosides from Centella asiatica. METHODS： Using total amounts of asiaticoside and hydroxy asiaticoside as investigation indexes， single factor and orthogonal test were used to investigate the enzyme amount， enzymolysis time， enzymolysis temperature， ethanol volume fraction， liquid material ratio and ultrasonic extraction time and optimize the extraction technology of asiaticosides from C. asiatica by ultrasonic-enzyme method， and verification test was conducted. RESULTS： Optimal extraction technology was as follow as cellulose dosage of 12 mg/g， 10-fold liquid material ratio added into 60％ ethanol， enzyme hydrolysis for 60 min at 60 ℃， ultrasonic assisted extraction for 50 min. Average extraction rate of total asiaticosides was 1.92％ （RSD＝1.83％， n＝3） in verification test. CONCLUSIONS： Ultrasonic-enzyme method is stable and feasible for the extraction technology of asiaticosides from C. asiatica.