OBJECTIVE： To investigate the effects of simvastatin intensive treatment on the Postoperative Related Indexes of patients with acute coronary syndrome（ACS） underwent percutaneous coronary intervention（PCI）. METHODS： 106 patients with were included in the study and randomly divided into observation group （53 cases） and control group （53 cases）. Both groups were given aspirin 100 mg，qd+clopidogrel 75 mg，qd before PCI for 4 weeks； observation group was additionally given Simvastatin tablet orally 20 mg before supper 15 d before surgery. TC， TG， LDL-C， HDL-C， hs-CRP， IL-6 and IL-18 levels， LVEF， the occurrence of coronary artery restenosis were detected in 2 groups before surgery and 6 months after surgery. The occurrence of ADR was recorded during treatment. RESULTS： There was no statistical significance in the levels of TG， TC， LDL-C and HDL-C between 2 groups before surgery and 6 months after surgery （P＞0.05）. There was no statistical significance in hs-CRP， IL-18，IL-6 and LVEF levels between 2 groups before surgery（P＞0.05）. 6 months after surgery， hs-CRP， IL-6，IL-18 and LVEF levels of 2 groups were significantly higher than before treatment； hs-CRP， IL-6 and IL-18 levels of observation group were significantly lower than those of control group， and LVEF was significantly higher than control group， with statistical significance （P＜0.05）. The incidence of coronary artery restenosis in observation group was significantly lower than control group， with statistical significance （P＜0.05）. No ADR was found in 2 groups during treatment. CONCLUSIONS： Preoperative simvastatin intensive treatment can effectively reduce cardiovascular inflammation degree in patients with ACS after PCI， prevent the formation of coronary artery thrombus， and reduce the incidence of coronary artery restenosis so as to effectively improve the prognosis and don’t increase the incidence of ADR.