OBJECTIVE： To investigate the application of key monitoring varieties among adjuvant drugs in medical institutions of Yunnan province， and to provide reference for the formulation of related policy and the promotion of clinical rational drug use. METHODS： The related data of key monitoring varieties in medical institutions of Yunnan province during Jan. 1st-Mar. 31st， 2015 were investigated and analyzed statistically. RESULTS： The data with highest effective rate were reported by tertiary hospitals， being 93.94％. Among top 10 drugs in the list of consumption sum， the number of key monitoring varieties was the highest in tertiary hospitals， being （5.50±2.12） varieties averagely. The consumption sum of key monitoring varieties in tertiary hospitals took up the highest proportion in total consumption sum of hospitalization drug， being（31.94±16.99）％ averagely； being（26.13±11.93）％ and （22.14±16.39）％ in second level hospitals and first level hospitals. Among top 10 drugs in the list of consumption sum， the consumption sum of key monitoring varieties in second level hospitals took up the highest proportion in total consumption sum of hospitalization key monitoring varieties， being （50.34±26.87）％ in average， up to 98.53％； being （39.13±22.55）％ and （27.38±27.75）％ in tertiary hospitals and first level hospital. Among top 5 key monitoring types in the list of hospitalization consumption sum， safflower yellow pigment and omeprazole were involved in hospitals at various levels. CONCLUSIONS： Adjuvant drug use are widespread in medical institutions of Yunnan province. Key monitoring varieties are given priority to TCM injection and proton pump inhibitors. It is necessary to take effective measures， formulate and implement the corresponding supervision system so as to promote rational clinical drug use.