OBJECTIVE： To provide reference for rational use of oxycodone and acetaminophen in outpatient and emergency department. METHODS： By retrospective study， the application of oxycodone and acetaminophen in outpatient and emergency department of our hospital during 2013-2015 was analyzed statistically. RESULTS： During 2013-2015， there were 22 654 outpatient and emergency prescriptions of oxycodone and acetaminophen in our hospital. The prescription number， amount and consumption sum of oxycodone and acetaminophen were increasing year by year. Top 3 clinical departments of oxycodone and acetaminophen in the list of prescription number were orthopedics department （78.34％）， emergency department （15.52％） and oncology department （2.09％）. The age of patients using oxycodone and acetaminophen mainly aged 19-64 years old （78.62％）； the ratio of male to female was 1 ∶ 1.08.  The amount of oxycodone and acetaminophen was 5 mg， mainly 4 times a day （86.91％）. In all kinds of diagnosis， knee osseous arthritis （47.26％）， pain in waist and lower extremities （6.18％） and abdominal pain in dispute （5.92％） were top three. CONCLUSIONS： A large amount of oxycodone and acetaminophen were used in outpatient and emergency department of our hospital during 2013-2015； there is unreasonable drug use so that we need to strengthen management and standardize drug use.