OBJECTIVE： To investigate the characteristics and regularity of ADR induced by Iobitridol injection， and to provide reference for clinical drug use. METHODS： In retrospective study， the information of 72 patients suffering from ADR induced by Iobitridol injection were collected from our hospital during Jul. 2015 to Jul. 2016， and then statistical analysis was conducted in respects of age， gender， primary disease， organs/system involved in ADR， clinical manifestations， relationship evaluation and degree， occurrence time， outcomes， etc. RESULTS： Among 72 cases of ADR， the number of female was about twice of that in male. The age mainly distributed in the range of 50 to 80 years old （80.56％）. ADR mainly occurred in skin and its appendants （30.57％）， followed by systemic reactions （22.93％） and circulatory system （21.66％）. ADR occurred within 20 min after medication （38.89％）. 58.33％ of ADR patients were cured， and 41.67％ were recovered. CONCLUSIONS： During the application of Iobitridol injection， a detailed understanding should be obtained about the patient’s condition， medical history and the results of the examinations. Medical staff should inform the patient of the possible allergic symptoms， and do a good emergency preparation.