OBJECTIVE： To analyze the features of risperidone-induced leucocytopenia ADR. METHODS： Twenty-one ADR cases of risperidone-induced leucocytopenia reported by our hospital were collected and analyzed during 2004-2015. The characteristics of risperidone-induced leucocytopenia were discussed. RESULTS： Among 21 patients， there were 10 male and 11 female. The age was from 15 to 72 years old. Nine cases of patients were 31-40 years old （42.9％）. Most of the original disease was schizophrenia. Incubation period of leucocytopenia caused by risperidone was （28.6±21.4） d. Patients had no discomfort complain when leucocytopenia occurred. The lowest white blood cells reported was（3.1±0.5）×109 L－1. The leucocytopenia were improved after reduction， drug withdrawal and symptomatic treatment. CONCLUSIONS： Patients usually have no body discomfort complain when risperidone-induced leucocytopenia appears. Doctors should moniter ADR regularly， identify it earlier and treat carefully.