OBJECTIVE： To evaluate the effectiveness and security of Yishen huashi granules in the adjuvant treatment of chronic nephritis systematically， and to provide evidenced-based reference.  METHODS： Retrieved from CBM， CJFD， Wanfang database， VIP， Medline， PubMed， EMBase and Cochrane library， randomized controlled trials （RCTs） about Yishen huashi granules in the treatment of chronic nephritis were collected and related magazines were retrieved by hand. After selection and data extraction by 2 researchers independently， the quality of included literature was evaluated according to Jadad rating scale， and Meta-analysis was conducted by using Rev Man 5.3.5 software. RESULTS： A total of 8 RCTs were included， involving 1 028 patients. Total response rate of trial group [RR＝1.33，95％CI（1.24，1.42），P＜0.001] was significantly higher than that of control group. 24 h urine protein quantity [MD＝－0.32，95％CI（－0.40，－0.24），P＜0.001]， serum creatinine  [MD＝－22.38，95％CI（－23.37，－21.39），P＜0.001]， blood urea nitrogen [MD＝－1.45，95％CI（－2.05，－0.84），P＜0.001] were significantly lower than control group， with statistical significance. CONCLUSIONS： Based on routine treatment， Yishen huashi granules have good therapeutic efficacy for chronic nephritis， can reduce 24 h urine protein and improve renal function.