OBJECTIVE： To study the effects of the collaboration application of hospital information system （HIS） and “smart chain” inventory automation management system （SPD） in drug distribution enterprises on drug logistics management， and achieve the centralized distribution of drugs. METHODS： Related countermeasures in achieving the informatization and scientization of drug inventory management after the collaboration application of HIS and SPD were introduced， and effectiveness analysis was conducted for the inventory management by comparing related indicators before and after collaboration application. RESULTS： Through the establishment of “unified receiving platform” system and barcode technology that combined with HIS and SPD， drug barcode acceptance was achieved； setting drug fixed package and scanning fixed cards in outer packing in the “unified receiving platform” system can achieve automatic out-and into-storehouse and generating purchase plan； the collaboration application of HIS and SPD achieved drug concentration distribution. Compared with before， monthly inventory amount was decreased 27.07％ （P＜0.05） in the condition that both drug purchases and sales amount were increased， into-warehouse time of pharmacy acceptance was decreased from 6-12 s in each drug to 10-15 s in each order， pharmacy staff dropped from 2.5 to 2 persons. CONCLUSIONS： The collaboration application of HIS and SPD in drug logistics management has improved efficiency of warehouse， reduced drug inventory and achieved the informatization and scientization of drug inventory management.