OBJECTIVE： To investigate the effects of L-carnitine on inflammatory factor， oxidant stress index and cardiac function in patients with maintenance hemodialysis.  METHODS： One hundred and twenty maintenance hemodialysis patients selected from our hospital during Dec. 2014-Feb. 2016 were randomly divided into observation group and control group， with 60 cases in each group. Control group received maintenance hemodialysis for 1 month， and then was given rhEPO injection 3 000 IU subcutaneously， 3 times a week. Observation group was additionally given Levocarnitine for injection 2 g， iv， qod， 1 day after hemodialysis， on the basis of control group. Two groups were treated for consecutive 3 months. The levels of inflammatory factors （IL-6， TNF-α， CRP）， oxidant stress indexes （MDA， GSH-Px， SOD） and cardiac function indexes （CO， LVEF， LVST） were observed in 2 groups before and after treatment； the occurrence of ADR was recorded.  RESULTS： There was no statistical significance in inflammatory factor， oxidant stress index and cardiac fuaction before treatment between 2 groups （P＞0.05）. After treatment， the levels of IL-6， TNF-α， CRP and MDA in observation group were decreased significantly， while the levels of GSH-Px， SOD， CO and LVEF were increased significantly， compared to before treatment； the improvement of above indexes in observation group were significantly better than control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： L-carnitine can effectively alleviate the micro-inflammatory state in maintenance hemodialysis patients and protect myocardial function with good safety.