OBJECTIVE： To investigate therapeutic efficacy and safety of Acetic acid goserelin sustained-release implants （AGRI） in the treatment of ovary endometrium cyst （OEC） recurrence after laparoscopic enuleation of ovarian cyst. METHODS： Totally of 60 patients with OEC recurrence after laparoscopic enuleation of ovarian cyst in Zhangjiagang First People’s Hospital during Jan. 2013-Jan. 2015 were divided into control group and observation group according to random number table， with 30 cases in each group. Both groups were given Mifepristone tablets orally 25 mg， qd. Control group was given Gestrinone capsules orally 2.5 mg， twice a week. Observation group was given AGRI subcutaneously 3.6 mg， once a month. Both groups were treated for consecutive 6 months. Clinical efficacies of 2 groups were observed as well as the levels of serum follicle stimulating hormone （FSH）， luteinizing hormone （LH） and estradiol （E2）， VAS scores of dysmenorrheal and chronic pelvic pain before treatment， 3， 6 months after treatment. The occurrence of ADR and the prognosis of 12-month follow-up were observed in 2 groups. RESULTS： Total response rate of observation group was 86.67％， which was significantly higher than 70.00％ of control group， with statistical significance （P＜0.05）.  After 3 months of treatment， the levels of FSH and LH in 2 groups were decreased significantly compared to before treatment， with statistical significance （P＜0.05）； the level of E2 had no change； there was no statistical significance in the levels of FSH and LH between 2 groups （P＞0.05）； after 6 months of treatment， the levels of FSH， LH and E2 in 2 groups were decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. After 3 and 6 months of treatment， VAS score of dysmenorrheal and chronic pelvic pain in 2 groups were decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. The incidence of ADR in observation group was 40.00％， which was significantly higher than 16.70％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in recurrence rate between 2 groups （P＞0.05）. The recovery rate of menstruation in observation group was 86.67％， the rate of dominant follicle formation was 60.00％ and pregnancy rate was 53.33％， which were significantly higher than 46.67％， 46.67％ and 33.33％ of control group， with statistical significance （P＜0.05）. CONCLUSIONS： AGRI shows significant therapeutic efficacy for OEC recurrence after laparoscopic enuleation of ovarian cyst， can effectively relieve dysmenorrhea and chronic pelvic pain， increase the rate of pregnancy. There is still recurrent cases after drug withdrawal. The incidence of ADR is high， but the symptoms are mild.