OBJECTIVE： To study the safety of percutaneous administration of Hongzhi gutong cataplasm. METHODS： Rabbits were taken for single dose in complete skin irritation test （n＝4）， single dose in damaged skin irritation test （n＝4） and multiple doses in complete skin irritation test （n＝4）. The left and right sides of the skin respectively paste 3 cm×3 cm blank matrix and Hongzhi gutong cataplasm for 24 h （calculated by crude drug of 0.14 g）. After removing tape 1， 24， 48， 72 h， the erythema and edema in hair removal site of rabbits in the former 2 tests were observed； after 24 h of administration， the rabbits in the last group were administrated again after exposing the administration area for 1 h， repeated 3 times， the erythema and edema in hair removal site after removing tape the first， second time and 1， 24， 48， 72 h in the third time were respectively observed. RESULTS： In the 3 experiments， the scores of erythema and edema of all rabbits were 0， and skin irritation was evaluated as no irritation. CONCLUSIONS： Hongzhi gutong cataplasm has no skin irritation in rabbits.