OBJECTIVE： To optimize the extraction technology of Compound Rhodiolae crenulatae granule. METHODS： The pharmacodynamic index of learning and memory ability was used to screen the water extraction， water extraction and alcohol precipitation and alcohol extraction methods for Compound R. crenulatae granule in mice by Y-type water maze test. Using the comprehensive scores of salidroside， ferulic acid extraction amount and extraction yield as indexes， orthogonal test was used to optimize the ethanol volume fraction， extraction time， solvent amount and extraction times， and verification test was conducted. RESULTS： Products by alcohol extraction can significantly improve learning and memory ability in the 3 methods； the optimal extraction technology was confirmed to 8-fold 70％ ethanol reflux extracting for 3 times， 1.0 h each time. In verification test， average extraction amount of salidroside and ferulic acid were 4.884 mg/g and 1.669 mg/g， and average extraction yield was 33.52％ （all RSD＜2％， n＝3）. CONCLUSIONS： The optimized extraction technology is stable， reliable， simple and feasible， which can be used for industrial extraction of Compound R. crenulatae granule.