OBJECTIVE： To investigate the effects of pharmaceutical intervention after discharge on medication compliance and prognosis of patients with coronary artery disease after percutaneous coronary intervention（PCI） in primary hospital. METHODS： One hundred and eighty patients with coronary artery disease selected from our hospital after PCI during Jan. 2012 to May 2015 were divided into test group and control group according to whether the patients received pharmaceutical intervention after discharge， with 90 cases in each group. Control group received conventional pharmaceutical care and discharge education. Test group additionally received pharmaceutical intervention（pharmaceutical service files， telephone follow-up， patient education， etc.） after discharge. Medication compliance and occurrence of cardiovascular events were compared between 2 groups in 1 year after discharge. RESULTS： Within 1 year after discharge， the proportion of patients showing good compliance in test group was higher than control group， the proportion of patients showing partial and non compliance in test group were lower than control group； the incidence of heart failure and repeated revascularization， hospitalization mortality and total mortality of test group were significantly lower than control group， with statistical significance （P＜0.05）. CONCLUSIONS： Pharmaceutical intervention after discharge can improve the medication compliance of coronary artery disease patients after PCI in primary hospital， reduce the occurrence of cardiovascular events and improve the clinical prognosis.