OBJECTIVE： To investigate the protective effect of Tibetan medicine Compound Duoxuekang capsules on the acute lung injury in mice induced by lipopolysaccharide. METHODS： 60 KM mice were randomly divided into blank group， model group， dexamethasone group （positive control， 1 mg/kg） and Compound Duoxuekang high-dose， medium-dose， low-dose groups （3.6， 1.8， 0.9 g/kg， calculated by crude drug），10 in each group. Intragastrically administrated， mice in blank group and model group intragastrically administrated equal volume of normal saline， once a day. After 7 d of administration， except for blank group， mice in other groups intraperitoneally injected lipopolysaccharide to induce acute lung injury. After 6 h modeling， pathological changes in the lung tissue was observed， lung tissue water content was measured， superoxide dismutase （SOD）， glutathione peroxidase （GSH-Px）， malondialdehyde （MDA） levels in lung tissue and IL-6， TNF-α levels in serum were detected. RESULTS： Compared with blank group， mice in model group showed pathological changes in congestion and edema， inflammatory cell infiltration， obvious widened alveolar septum and alveolar wall； water content in lung tissue and IL-6， TNF-α levels in serum were significantly increased （P＜0.01）； SOD， GSH-Px levels in lung tissue were significantly decreased （P＜0.01）. Compared with model group， injury degree of lung tissue reduced to varying degrees in each treatment group， except for the water content， MDA level in lung tissue and TNF-α level in serum in Compound Duoxuekang capsules low-dose group； the above-mentioned indexes in other groups were significantly improved （P＜0.05 or P＜0.01）. CONCLUSIONS： Compound Duoxuekang capsules can obviously reduce mice’s oxidative stress and inflammatory response， and has certain protective effect on acute lung injury in mice.