OBJECTIVE： To investigate the protective effect of Compound ginkgo leaf granules on liver function damage of acute pancreatitis. METHODS： Totally 82 patients with severe acute pancreatitis （SAP） complicated with liver function damage selected from our hospital during Sept. 2013-Sept. 2015 were randomized into control group and observation group according to random number table， with 41 cases in each group. Control group was given SAP related routine therapy. On the basis of the control group， observation group was additionally given Compound ginkgo leaf granules 5 g added into warm boiled water 80 mL via nasogastric tube， tid， one week as a treatment course， for 2 courses. The remission time of abdominal pain， serum amylase recovery time， length of hospital stay and adverse drug reactions were observed in 2 groups. The levels of serum amylase， ALT， TBIL， AST， γ-GT， ALB， IL-6， TNF-α， creotoxin concentration， MDA， SOD， GSH-Px， total antioxidant capacity （TAC） and peripheral blood PMN NF-κB levels were determined in 2 groups before and after treatment. RESULTS： In control group， 3 patients withdrew from the study and 38 patients completed the study； in observation group， 6 patients withdrew from the study and 35 patients completed the study. The remission time of abdominal pain， recovery time of serum amylase and the length of hospital stay in observation group were significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in the levels of serum amylase， ALT， TBIL， AST， γ-GT， ALB， IL-6， TNF-α， creotoxin concentration， MDA， SOD， GSH-Px， TAC and NF-κB between 2 groups （P＞0.05）. After treatment， the levels of serum amylase， ALT， TBIL， AST， γ-GT， IL-6， TNF-α， creotoxin concentration， NF-κB and MDA in 2 groups were decreased significantly， while the levels of ALB， SOD， GSH-Px and TAC were increased significantly； the observation group was significantly lower or higher than the control group，with statistically significant （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Compound ginkgo leaf granules can significantly decrease serum amylase， protect liver function，  with good safety. The mechanismmay be inhibiting the release of inflammatory factors， improving oxidative stress reactions， reduce the concentration of creotoxin and inhibiting the activity of NF-κB.