OBJECTIVE： To explore effective pharmaceutical administration measures for the rational adjunctive drugs. METHODS： The effective pharmaceutical administration of adjunctive drugs in medical institutions of Sichuan province was introduced， including establishing key monitoring management system of adjunctive drugs （establishing and implementing prescription review system， rational drug use training， strict supervision and examination） and playing promotion effect of provincial pharmaceutical quality management control center on medical institutions， etc. The effects of pharmaceutical administration in 18 third-grade class- A medical institutions were evaluated through statistically analyzing rational utilization ratio， drug ratio， consumption sum of adjunctive drugs. RESULTS： Up to May 2016， key monitoring management system of hospital adjunctive drugs had been established and improved in medical institutions over Sichuan province. The rational utilization ratio of adjunctive drugs in 18 medical institutions increased from 69.41％ in Jan. 2016 to 79.05％ in May 2016； drug ratio decreased from 29.22％ to 27.93％. The monthly consumption sum of adjunctive drugs decreased from 22 970 000 yuan in Apr. 2015 to 17 380 000 yuan in Apr. 2016 （decreasing by 20.49％）. CONCLUSIONS： Medical institutions of Sichuan province conduct effective pharmaceutical administration of adjunctive drugs through establishing the key monitoring management system for medical institutions and playing the role of the provincial pharmaceutical quality management control center for the supervision.