OBJECTIVE： To investigate the suspected influential factors of ADR induced by Reduning injection， and to provide scientific evidence for safe and rational drug use in the clinic. METHODS： ADR reports induced by Reduning injection during Jan. 2005-Jun. 2015 were retrieved from VIP， CJFD and Wangfang database. Logistic regression multiple factor analysis was used to study clinical characteristics of Reduning injection and influential factors of ADR induced by Reduning injection. RESULTS： 176 cases were selected. Main ADR induced by Reduning injection was lesion of skin and its appendents （42.61％）， followed by systemic ADR （24.43％）， digestive system ADR （13.64％）， etc. The main influential factors were gender， age， allergy history， past medical history， drug combination， dose and intravenous drip rate， etc. CONCLUSIONS： ADR induced by Reduning injection may be related to age， allergy history， intravenous drip rate， drug combination， etc. Medical staff should carefully inquiry previous history of allergy and medication， implement individualized treatment dialectically， strengthen medication monitoring， enhance the awareness of prevention to reduce the occurrence of ADR.