OBJECTIVE： To observe effect and safety of continuous renal replacement therapy （CRRT） combined with different doses of xuebijing sepsis patients with acute kidney injury （AKI）. METHODS： One hundred and four patients diagnosed as sepsis complicated with AKI were collected from ICU of our hospital during Jun. 2012 to Aug. 2015. They were divided into small-dose group， medium-dose group， large-dose group and control group according to random number table， with 26 cases in each group. Four groups received routine treatment. Small-dose group was given Xuebijing injection 50 mL added into 0.9％ Sodium chloride injection （NS） 100 mL， ivgtt， bid； medium-dose group was given Xuebijing injection 100 mL added into NS 100 mL， ivgtt， bid； large-dose group was given Xuebijing injection 100 mL added into NS 100 mL， ivgtt， qid. All patients were treated for 1 week. The levels of IL-6， TNF-α and hs-CRP were observed in 4 groups before and after treatment； renal function indexes as BUN， SCr and CysC， blood coagulation function indexes as PT， APTT and Fib were also observed as well as APACHEⅡ score and Marshall score. The occurrence of ADR were recorded during treatment. RESULTS： Ninety-five cases meeting the criteria were finally included in the study after 9 cases withdrew from the study， and there were 23， 24， 25， 23 cases in small-dose group， medium-dose group， large-dose group and control group， respectively. Before treatment， there was no statistical significance in above indexes among 4 groups （P＞0.05）. After treatment， the serum levels of IL-6， TNF-α， CRP， PT and APTT， APACHEⅡ score and Marshall score in 4 groups were all decreased significantly， while the serum levels of BUN， SCr， CysC and Fib were increased significantly； the improvement of above indexes in small-dose group， medium-dose group and large-dose group were all better than in control group， and the large-dose group was significantly better than the small-dose group and medium-dose group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR among 4 groups （P＞0.05）. CONCLUSIONS： Large-dose xuebijing combined with CRRT can effectively inhibit inflammatory reaction in sepsis patients with AKI， improves renal function and coagulation function， and dose not increase the risk of ADR.