OBJECTIVE： To provide reference for ensuring the drug safety using for children in family. METHODS： Delphi method was used， four-round expert questionnaires were prepared to investigate 39 related experts （physicians and pharmacists）， the data was statistically analyzed， and the core information screening of the drug safety using for children in family was selected and summarized. RESULTS： Totally 39 questionnaires were sent out， 39 were effectively received， with effective recovery of 100％， namely the positive coefficient of the surveyed experts in four-round questionnaire was 100％. According to the statistical analysis， the authority coefficient of the 2-4 round questionnaires was 0.80±0.10， 0.81±0.02， 0.82±0.02； expert coordination coefficient values were 0.122， 0.125 and 0.291， respectively. Based on the statistical indexes， 4 classes （45 items） of core information about drug safety using for children in family were screened， which met the mean value no less than 4.0 scores， coefficient of variation was lower than 0.25， percentage of non-importance was lower than 50％. CONCLUSIONS： The selected 45 core information is important and high-concentrated by experts， which is representative. The methodology and process can provide reference for other research of drug evaluation and intervention for children.