OBJECTIVE： To establish a method for the determination of 9 residual organic solvents in blonanserin as methanol， alcohol， isopropyl alcohol， acetonitrile， dichloromethane， hexane， ethyl acetate， tetrahydrofuran and methylbenzene. METHODS： Headspace gas chromatography was adopted. The determination was performed on DB-624 capillary column using temperature programming. The inlet temperature was 150 ℃， and flame ionization detector was used with temperature of 250 ℃. High purity nitrogen was used as carrier gas with flow rate of 2.8 mL/min. The split ratio was 1 ∶ 1， and headspace sample size was 1 mL. Headspace heating temperature was 90 ℃， and equilibration time was 35 min. RESULTS： The linear ranges of methanol， alcohol， isopropyl alcohol， acetonitrile， dichloromethane， hexane， ethyl acetate， tetrahydrofuran and methylbenzene were 6-1 500 μg/mL（r＝0.999 8），10-2 500 μg/mL（r＝0.999 9），10-2 500 μg/mL（r＝0.999 8）， 0.82-205 μg/mL（r＝0.999 4），1.2-300 μg/mL（r＝0.999 5）， 0.58-145 μg/mL（r＝0.999 4），10-2 500 μg/mL（r＝0.999 9），1.44-360 μg/mL（r＝0.999 6），1.78-445 μg/mL（r＝0.999 5）， respectively. The limits of quantitation were 17.71， 6.02， 3.17， 7.45， 1.53， 0.69， 0.93， 1.01， 0.22 μg/mL； the limits of detection were 5.89， 1.90， 1.05， 2.48， 0.51， 0.23， 0.31， 0.33， 0.07 μg/mL， respectively. RSDs of precision and stability tests were all lower than 3.0％， and isopropanol was found in repeatability test （RSD＝2.1％）. The average recoveries ranged 96.67％-102.66％ （RSD＝1.9％，n＝9），96.00％-101.83％（RSD＝1.9％，n＝9）， 97.17％-101.50％（RSD＝1.4％，n＝9）， 96.97％-102.44％（RSD＝2.2％，n＝9），95.83％-103.33％（RSD＝2.5％，n＝9）， 95.83％-100.28％（RSD＝1.9％，n＝9）， 98.17％-101.25％（RSD＝1.0％，n＝9）， 96.55％-102.30％（RSD＝1.9％，n＝9），96.30％-102.22％（RSD＝1.8％，n＝9）， respectively. CONCLUSIONS： The method is simple， rapid， accurate and suitable for simultaneous determination of 9 residual organic solvents in blonanserin as methanol， alcohol， isopropyl alcohol， acetonitrile， dichloromethane， hexane， ethyl acetate， tetrahydrofuran and methylbenzene.