OBJECTIVE： To investigate the effects of application timing of carboporst tromethamine on postpartum hemorrhage and hemodynamics of cesarean section women with centralplacenta previa. METHODS： Totally 138 parturient women with central placenta previa selected from our hospital during Jan.-Dec. 2015 were divided into observation group and control group according to random number table， with 69 cases in each group. Both groups received cesarean section. Control group was given Carboporst tromethamine injection 250 μg on uterine body after the delivery of placenta. Observation group was given Carboporst tromethamine injection 250 μg on corpora uteri immediately after umbilical cord cutting. The operation duration， intraoperative and postoperative blood loss were observed in 2 groups. The preoperative and postoperative 24 h hemodynamic index， coagulation function and corpora uteri were compared between 2 groups. RESULTS： The operation duration of observation group was significantly shorter than control group； intraoperative blood loss and 24h blood loss of observation group were significantly less than control group， with statistical significance （P＜0.05）. There was no statistical significance in preoperative hemodynamic index and coagulation function index between 2 groups before surgery （P＞0.05）. 24 h after surgery， SBP， DBP， MAP， FIB and D-D of 2 groups were decreased significantly， while HR of them were increased significantly； the observation group was significantly better than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR （15.94％ vs. 13.04％） between 2 groups （P＞0.05）. CONCLUSIONS： Carboporst tromethamine after omphalotomy via uterine body helps to shorten the operation time， reduce intraoperative blood loss， maintain hemodynamic indexes stable and improve coagulation function of cesarean section women with central placenta previa ，with good safety.