OBJECTIVE： To investigate the similarity of dissolution curves between generic preparations and reference preparations of Bisacodyl enteric-coated tablets in various dissolution mediums， and to provide reference for improving production technology and internal quality of generic preparations. METHODS： Paddle method was adopted with rotation speed of 75 r/min. The dissolution test was performed using 1 000 mL pH 6.0 phosphate buffer solution， pH 6.8 phosphate buffer solution， water containing 2％ sodium lauryl sulfate. HPLC method was used to determine average accumulative dissolution of main components from 3 kinds of generic preparations and reference preparations at different time points to draw out dissolution curves. Similarity factor （f2） method was used to the similarity of dissolution curves. RESULTS：Dissolution curves of reference preparations were basically the same in 3 kinds of dissolution mediums. But the dissolution curve f2 of one generic preparation among 3 manufactures to dissolution curve of reference preparation were ≥50， namely the similarity. CONCLUSIONS： The quality of generic Bisacodyl enteric-coated tablets produced by different manufacturers is obviously different； the generic preparations needs to be further improved in the production technology and internal quality. For domestic generic preparation， it is necessary to strengthen the real-time monitoring of its dissolution curve， to ensure the drug quality.