OBJECTIVE： To optimize the formulation of Compound tripterygium hypoglaucum gel. METHODS： Using the comprehensive score （total score was 15.0） composed by forming property， glossiness， uniformity， viscosity， pH， spreadable property and stability as indexes， using the usage amount of carbomer 940， propylene glycol， triethanolamine and extracts in formula as study factors， orthogonal test was designed to optimized the formulation of Compound tripterygium hypoglaucum gel， and the verification test was conducted. RESULTS： The optimal matrix formulation was as follow as carbomer 940 1.0 g， azone 2.0 g， sodium bisulfite 0.4 g， extracts 50 mL， propylene glycol 10 g， triethanolamine 1.0 g， adding water to 100 g. The average comprehensive score of the gel in verification test was 14.8 （RSD＝1.35％， n＝3）. CONCLUSIONS： The optimized formulation of Compound tripterygium hypoglaucum gel shows good forming property， the quality meets the requirements.