OBJECTIVE： To investigate the utilization and trend of drugs for herpes zoster patients from 22 hospitals of Shanghai area， and to provide reference for rational use of drugs. METHODS： The utilization of drugs for herpes zoster patients from 22 hospitals of Shanghai area during 2013-2015 was analyzed statistically in respects of proportion of patients， consumption sum， DDDs， DDC， etc. RESULTS： Herpes zoster was more likely to occur in adults， mostly in more than 45 year-old group （＞75％）. The proportions of patients of neurotrophic antivirals， anti-herpes virus and acesodyne drugs ranked in the top three. Topical， immunomodulatory and glucocorticoid drugs accounted for a certain proportion. Among antivirals， the consumption sum and DDDs of valaciclovir ranked the first place， and DDC of brivudine was the highest. Among acesodyne， the proportions of patients of antiepileptic drugs was the highest （13.78％）， and its compound growth rate was also the highest （30.77％）； the number of patients of gabapentin was the largest. Among neurotrophic drugs， the proportions of patients of mecobalamine was the highest （32.98％）. Among immunomodulatory drugs， the number of patients of thymalfasin was the largest， which may be irrational. CONCLUSIONS： The treatment of herpes zoster in Shanghai area is basically in accordance with the guidelines. The irrational use of immunomodulatory drugs should be paid attention to and supervised.