OBJECTIVE： To investigate the role of clinical pharmacists in the therapy for viral encephalitis complicating with secondary epilepsy. METHODS： Clinical pharmacists participated in the drug treatment for a patient with viral encephalitis complicating with secondary epilepsy， assisted doctor to monitor the blood concentration of antiepileptic drugs， drug interactions and to optimize antibiotics treatment plan. Clinical pharmacists suggested giving Cefoperazone sodium and sulbactam sodium for injection 3 g， ivgtt， q8 h+Vancomycin hydrochloride for injection 1 g， ivgtt， q12 h， instead of meropenem for anti-infective treatment； adjusting the dose of valproic acid to 0.4 g， ivgtt， q6 h， for antiepileptic treatment， avoiding drug interaction， closely monitoring vital sign. It was suggested to stop 18 kinds of Amino acid infections and glyceol and fructose so as to exclude drug fever. RESULTS： Physicians adopted the suggestion of clinical pharmacists. Patient’s condition was effectively controlled after 48 d treatment and then the patient was discharged from the hospital. CONCLUSIONS： Clinical pharmacists participate in the therapy for viral encephalitis complicating with secondary epilepsy and assist physicians to optimize therapy plan according to blood concentration can minimize the occurrence of drug interactions and guaratee the satety and effectivenes of clinical therapy.