OBJECTIVE： To explore the application and feasibility of tracer methodology in the continuous improvement of high-alert medications management in the hospital， and to improve the quality of high-alert medications management and ensure the safety of clinical medication. METHODS： According to the theory and requirements of tracer methodology， a series of interventions were applied to the management of high-alert medications in our hospital. The comparisons on the mastery of high-alert medications knowledge， review and evaluation results and the incidence of adverse events were conducted before and after applying tracer methodology， so as to evaluate the improvement effect of tracer methodology on high-alert medications management. RESULTS： After implementing intervention measures such as the reduction of high-alert medications list and medical staff training about high-alert medications， compared to before management， medical staffs had improved the knowledge level of high-alert medications （the average awareness rate increased from 69.6％ to 88.5％）； the review and evaluation results had been improved significantly （the proportion of the terms with qualified level evaluation results or above increased from 66.67％ to 88.89％）； the incidence of adverse events was reduced （from 0.321％ to 0.139％）. CONCLUSIONS： The tracer methodology has a significant effect on the management of high-alert medications in our hospital. It is feasible and can be widely used in the management of high-alert medications in the hospitals.