OBJECTIVE： To investigate anti-inflammatory， analgesic， gastric mucosa-protective and spasmolysis effects of Li medicine Fengliao changweikang granule （FMCWK） in juvenile rats/mice. METHODS： 60 SD juvenile rats were randomly divided into blank group （distilled water）， Baohe pills group （TCM positive control， 0.98 g/kg， calculated by crude drug）， omeprazole group （chemicals positive control， 4.36×10－3 g/kg） and FMCWK low-dose， medium-dose and high-dose groups （4.88， 9.75， 19.50 g/kg， calculated by crude drug）， with 10 rats in each group. They were given relevant medicine intragastrically， once a day， for consecutive 7 d. The secretion of gastric juice， pH value， total acidity， 1 h total acid output and the activity of pepsase were all determined. 70 SD juvenile rats were grouped with same method， and gastric mucosal lesion model group （distilled water） was also set up. They were given relevant medicine intragastrically， once a day， for consecutive 4 d. The index of gastric mucosal lesion was determined. 60 KM juvenile mice were randomly divided into blank group （distilled water）， indometacin group （positive control， 9.79×10－3 g/kg） and FMWK low-dose， medium-dose and high-dose groups （4.88， 9.75， 19.50 g/kg， calculated by crude drug）， with 12 mice in each group. They were given relevant medicine intragastrically， once a day， for consecutive 4 d. The peritoneal capillary permeability test was adopted to determine the content of Evans blue solution in mice； acetic acid induced pain method was used to determine the number of writhing within 15 min； anti-inflammatory and analgesic effects of FMCWK were investigated. The gastric fundus strips with the length of 2 cm was collected to induce spasm by BaCl2. The effects of FMCWK （29， 87， 294 g/L， calculated by crude drug） and Baohe pills （22 g/L， calculated by crude drug） on gastric fundus strips tension were investigated and the spasmolysis percentage was also calculated to investigate its spasmolysis effect. RESULTS： Compared with blank group， high-dose FMCWK significantly increased pH of gastric juice， and decreased total acidity， 1 h total acid output of rats， decreased the content of Evans blue and the number of writhing within 15 min in mice （P＜0.05 or P＜0.01）； different concentrations of FMCWK significantly decreased gastric fundus strips tension while decreased spasmolysis percentage of rats （P＜0.01）. Compared with model group， medium-dose and high-dose FMCWK significantly decreased the index of gastric mucosal lesion in rats （P＜0.05 or P＜0.01）. CONCLUSIONS： FMCWK possesses certain anti-inflammatory， analgesic， gastric mucosa-protective and spasmolysis effects for juvenile rats/mice.