OBJECTIVE： To establish a method for the simultaneous determination of paracetamol， amantadine hydrochloride， caffeine， chlorphenamine maleate in Compound paracetamol and amantadine hydrochloride tablet. METHODS： GC was performed on the column of HP-5 sillica capillary， temperature programmed， detector was FID detector， with the temperature of 300 ℃， carrier gas was nitrogen gas， the flow rate is 1.5 mL/min， the split ratio was 20 ∶ 1 and injection volume was 1 μL. RESULTS： The linear range was 156.0-4 990.4 μg/mL for paracetamol， 125.7-4 023.2 μg/mL for amantadine hydrochloride， 19.14-612.4 μg/mL for caffeine and 2.515-80.48 μg/mL for chlorphenamine maleate（all r＝0.999 9）； the limits of quantification were 1.4， 0.5， 1.1， 0.9 ng， limits of detection were 0.4， 0.2， 0.3， 0.3 ng； RSDs of precision， stability and reproducibility tests were lower than 2.0％； recoveries were 99.59％-101.77％（RSD＝0.8％，n＝9），99.56％-101.80％ （RSD＝0.7％，n＝9）， 98.44％-100.83％（RSD＝0.7％，n＝9） and 100.05％-101.91％（RSD＝0.6％，n＝9）， respectively. CONCLUSIONS： This method is simple， rapid， accurate and reliable， and suitable for the simultaneous determination of paracetamol， amantadine hydrochloride， caffeine， chlorphenamine maleate in Compound paracetamol and amantadine hydrochloride tablet.